CBD and building up a tolerance

Posted in Science of CBD

CBD and building up a tolerance

CBD AND BUILDING UP A TOLERANCE 

Because CBD works best when taken regularly, many users report having to increase their dosage to feel the same effects.

CBD tolerance is a hotly contested subject; some claiming that early studies show no evidence that one’s tolerance to CBD builds up over time, and others adamant that, just like almost anything, our body builds up a tolerance to CBD.  

While THC tolerance is overwhelmingly accepted, CBD tolerance is a little more tricky.  This is because CBD interacts differently with our endocannabinoid system and doesn’t bind to the CB1 and CB2 cannabinoid receptors in the same way that THC does.  The specific way CBD binds to the receptors leads experts to believe that they don’t become desensitized in the process (the way they do with THC.)  

All of the research currently available strongly suggests that, not only does CBD not lead to tolerance, it actually creates what is known as reverse tolerance, or drug sensitization.  Reverse tolerance is the belief that the continued use of a substance actually brings down our body’s tolerance level, eventually leading the user to be able to consume less and achieve the same result.

Because CBD promotes increased receptor activity, the complete opposite to THC, many users have reported being able to decrease their intake of CBD over time.  Other receptors such as GABA and NMDA have also shown to respond to CBD, and play an important role in reverse tolerance.

It’s important to remember that all of our bodies are different and react to things differently.  There is lots of anecdotal evidence from users who claim to have built up a tolerance to CBD.  On the other hand, the research that has been done so far suggests this should not generally be the case.  Until more research is conducted, the topic of CBD tolerance will remain a contested one.

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Disclaimer: We recommend consulting with a qualified medical doctor or veterinarian when preparing a treatment plan for any and all diseases or ailments. Do not exceed more than 20mg of CBD(Cannabidiol) in your daily dose as per South African government regulations. Regulation amending s22(A)2 of the Medicine and Related Substance Act, 1965 (Act no.101 of 1965) Published 23 May 2019

Sources:

https://www.sciencedirect.com/science/article/abs/pii/S0149763418302665

https://www.mdpi.com/1424-8247/3/7/2197/htm

https://pubmed.ncbi.nlm.nih.gov/30031028/

https://pubmed.ncbi.nlm.nih.gov/22129319/