Although the cannabis plant has been around for literally centuries, with the first recorded use of cannabis as a medicinal drug documented in 2737 BC by the Chinese emperor Shen Nung, the CBD (cannabidiol) compound was only isolated by scientists in 1940 with the chemical structure being defined even later in 1963. It wasn’t until 1990 that scientists figured out the mammalian brain has receptor sites that respond to compounds in cannabis resin – called cannabinoid receptors – and that these are more abundant than any other known neurotransmitter receptor. These receptor sites are part of a molecular signaling system within the body called the endocannabinoid system.
While this biological system performs many known tasks and is still being extensively researched, its main goal appears to be maintaining optimal balance within the body (homeostasis) despite changes or deficiencies in the external environment. The body reacts to imbalances by synthesizing endocannabinoids to stimulate a chemical response and interaction within the appropriate cannabinoid receptor CBD vaping e-liquids, with more products hitting the major markets regularly.
Why should you supplement your diet with CBD oil extract?
TIn many cases, due to modern lifestyles and other stressors, there may be a deficiency called Clinical Endocannabinoid Deficiency. The body produces some of its own endocannabinoids, but we get most of them from the food we eat. One study linked a deficiency of Omega 3s with mood changes caused by poor endocannabinoid regulation. A number of things can be caused by poor endocannabinoid regulation. There could be an overabundance of enzymes that break down cannabinoids. It could be outside sources such as medications or environmental toxins that decrease endocannabinoid system functioning.
There are many symptoms that may suggest an underlying endocannabinoid deficiency, with some of the most common including:
- Chronic insomnia
- Recurring anxiety
- Mood imbalances
- Inflammation issues, including arthritis
- Recurring skin conditions such as eczema
- Bone loss
- Chronic pain
- Muscle spasms
How can hemp derived CBD oil help you?
The cannabinoids found in the hemp plant are equivalent to the endocannabinoids naturally produced by the body. These endocannabinoids can be used to supplement a deficiency. CBD is one of the 100+ cannabinoids found in the cannabis plant. It is the second most abundant compound in hemp. Specifically, representing up to 40% of its extracts. Research shows CBD interacts with the cannabinoid receptors within the endocannabinoid system to elicit chemical responses throughout the brain and body, helping to bring about homeostasis within all internal systems. By stimulating and supporting your endocannabinoid system one can find relief from a multitude of illnesses and conditions.
What types of CBD oil are there?
Now that you understand why supplementing with cannabinoids is important, you need to understand the difference between water-soluble CBD and CBD oil.
In its natural form, CBD oil isn’t water soluble, as the hemp plant is full of oils. This can be a problem because our bodies are made up largely of water… water and oil don’t mix. Another issue is something called “first-pass metabolism” which is a phenomenon of drug metabolism that causes the concentration of a drug to be greatly reduced before it reaches systemic circulation when swallowed. This reduction causes a decrease in bioavailability. *Bioavailability is the degree and rate at which an administered drug is absorbed by the body’s circulatory system.
To make CBD oil water-soluble, it must be reengineered in a laboratory with expensive equipment under very specific conditions. CBD oil is converted into nano-sized particles or microscopic droplets. This can then more readily mix into your blood when you take it, with a bioavailability rate of up to 90% when CBD is processed via this method. CBD oil made outside of a lab will not be water-soluble and thus the bioavailability will be, at best case, only 20% of the actual CBD dosage taken.
This is why CBD oil can range greatly in price as well as in the milligrams of CBD present in a product, and also why it’s important to know whether you are taking an oil-based or water-soluble CBD product created in a lab under strict conditions, as bioavailability will dictate how much CBD your body is actually absorbing irregardless of the amount listed on a product label.
So what should my CBD dosage be?
Although we are still very much in the research phase of understanding all the myriad benefits to supplementing with cannabinoids, most scientists suggest that between 2mg to 10mg is a balanced daily maintenance dose to start at, depending on the severity of your symptoms and of your personal endocannabinoid deficiency. There is a way to calculate CBD dosage of a CBD oil tincture. Divide the total liquid volume present in the bottle by the amount of CBD listed on the label. Then you multiply by the assumed bioavailability rate (we assume 80% for water-soluble products, and 20% for oil-based products). As an example CBD dosage calculation, Cibdol CBD hemp oil in a 10ml bottle containing 500mg CBD would result in the following CBD dosage per .5ml administered: 500mg/20 doses = 25mg CBD per .5ml dosage; 25mg*80% assumed bioavailability rate = 20mg CBD per .5ml dose.
Once you determine your personal starting CBD dosage level, continue to follow this formula of how much CBD oil to take for an initial 7 days. After the first week, evaluate how you feel and then go up or down as needed in CBD dosage administered until you find your own personal sweet spot. You may also want to consider trying CBD vape oil e-liquids or topical products such as CBD lotions and CBD balms, which have differing bioavailability rates when compared to CBD oils, tinctures, and CBD capsules. Remember: every body is different and so is every endocannabinoid system..
*Do not exceed more than 20mg of CBD(Cannabidiol) in your daily dose as per South African government regulations. Regulation amending s22(A)2 of the Medicine and Related Substance Act, 1965 (Act no.101 of 1965) Published 23 May 2019.
Always consult your physician or veterinarian when adding to you or your pet’s diet. These products are not intended to diagnose, treat, or cure any disease, and no claims regarding such are made. Products have not been evaluated by the MCC or the FDA.